Alloimmune disorders of pregnancy anaemia, thrombocytopenia, and neutropenia in the fetus and newborn

Cover of: Alloimmune disorders of pregnancy |

Published by Cambridge University Press in Cambridge, New York .

Written in English

Read online

Subjects:

  • Blood diseases in pregnancy.,
  • Fetus -- Diseases.,
  • Pregnancy -- Complications.,
  • Anemia, Hemolytic, Autoimmune -- Infant, Newborn.,
  • Fetal Diseases.,
  • Infant, Newborn, Diseases.,
  • Neutropenia -- Infant, Newborn.,
  • Pregnancy Complications.,
  • Prenatal Diagnosis.,
  • Thrombocytopenia -- Infant, Newborn.

Edition Notes

Includes bibliographical references and index.

Book details

Statement[edited by] Andrew Hadley and Peter Soothill.
ContributionsHadley, Andrew, 1957-, Soothill, Peter, 1957-
Classifications
LC ClassificationsRG572 .A456 2002
The Physical Object
Paginationxii, 282 p.
Number of Pages282
ID Numbers
Open LibraryOL22464271M
ISBN 100521781205

Download Alloimmune disorders of pregnancy

This book will serve as a useful resource for the many participants in multidisciplinary teams that manage alloimmune disorders in pregnancy. It should serve to enhance communication and coordination among investigators and clinical specialists in each of the contributing fields, thus achieving the editors' : $ "This book will serve as a useful resource for the Alloimmune disorders of pregnancy book participants in multidisciplinary teams that manage alloimmune disorders in pregnancy.

It should serve to enhance communication and coordination among investigators and clinical specialists in each of the contributing fields, thus achieving the Format: Printed Access Code. Alloimmune Disorders of Pregnancy Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn alloimmune thrombocytopenia and alloimmune neutropenia are all consequences Alloimmune disorders of pregnancy book maternal immunisation to fetal blood cells.

paediatricians, immunologists, laboratory technicians, midwives and research scientists. This book has been. Alloimmune Disorders of Pregnancy by Andrew Hadley,available at Book Depository with free delivery worldwide.

Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn Edited by Andrew Hadley and Peter Soothill. Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a blood disorder that affects pregnant women and their babies.

NAIT was first reported in the literature in and is estimated to occur in as many as 1 in live births. NAIT results in the destruction of platelets in the fetus or infant due to a mismatch between the mother’s platelets and those of the baby. The alloimmune disorders of pregnancy arise from maternal immunisation to fetal blood cells.

The effective prevention, diagnosis and management of these disorders involves a team management approach. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology.

Alloimmune disorders of pregnancy Anaemia, thrombocytopenia and neutropenia in the fetus and newborn Collectively known as the alloimmune cytopenias, haemolytic disease of the fetus and newborn, alloimmune thrombocytopenia and alloimmune neutropenia are all consequences of maternal immunization to fetal blood cells.

Neonatal alloimmune thrombocytopenia (NAITP, NAIT, NATP or NAT) is a disease that affects babies in which the platelet count is decreased because the mother's immune system attacks her fetus' or newborn's platelets.A low platelet count increases the risk of bleeding in the fetus and newborn.

If the bleeding occurs in the brain, there may be long-term lty: Pediatrics. Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn.

[Andrew Hadley; Peter Soothill;] -- Collectively known as the alloimmune cytopenias, hemolytic disease of the fetus and newborn, alloimmune thrombocytopenia and alloimmune neutropenia are all consequences of maternal immunisation to. regard, this book has much to commend it. It will provide the prospective reader with a comprehensive, well-referenced and up to date overview of alloimmune disorders of pregnancy.

This is a confusing area of fetal medicine and the explanations and practical approach that the book presents wdl Alloimmune disorders of pregnancy book it Author: William Martin.

Pediatric and Perinatal Pathology: SY ALLOIMMUNE DISORDERS OF PREGNANCY Ona Marie Faye-Petersen Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA There is mounting evidence that several placental pathologic entities associated with fetal intrauterine growth restriction and poor and recurrent pregnancy Author: Ona Marie Faye-Petersen.

It will provide the prospective reader with a comprehensive, well-referenced and up to date overview of alloimmune disorders of pregnancy. This is a confusing area of fetal medicine and the explanations and practical approach that the book presents wdl make it useful not only for both those within fetal and transfusion medicine but also those.

This is the first book which contains a comprehensive overview of all known alloimmune cytopenias owing to maternal immunization to foetal red cells, platelets and neutrophils.

This book clearly meets the requirement of having all the alloimmune disorders of pregnancy together and in addition shows their similarities and differences. It shows the problems in both aspects – the state of.

Both autoimmune and alloimmune causes of IID should be thoroughly investigated and addressed. Immunologic acceptance of the implanting embryo is essential for pregnancy to occur. When confronted by foreign proteins (bacteria viruses, foreign tissue grafts/transplantation), the body’s immune system goes on the attack.

Thrombocytopenia is common in mothers and newborns and usually is caused by an increased rate of platelet reference range of a normal platelet count in nonpregnant women and newborns is ,/µL; however, mean platelet counts in pregnant women generally are lower.

Thrombocytopenia in pregnancy has many common causes, including. Types of Autoimmune Diseases in Pregnancy Autoimmune conditions occur when immune system abnormalities cause inflammation or pain in the joints, muscles, heart, lungs, kidneys, and skin.

For decades, women with these conditions were advised to avoid pregnancy because of the risks, which can include miscarriage, preterm labor, and preeclampsia.

Kamphuis MM, Paridaans N, Porcelijn L, et al. Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review. BJOG ; Regan F, Lees CC, Jones B, et al.

Prenatal Management of Pregnancies at Risk of Fetal Neonatal Alloimmune Thrombocytopenia (FNAIT): Scientific Impact Paper No. J.B. Bussel, J.M. Despotovic, in Reference Module in Biomedical Sciences, Perinatal Alloimmune Disorders.

Alloantibodies can result in significant cytopenias in the newborn period. In particular, two alloantibody-mediated complications of pregnancy cause significant morbidity and mortality in the fetus and neonate: hemolytic disease of the fetus and newborn (HDFN, RBC) and fetal and.

Alloimmunization also known as isoimmunization, during pregnancy is the production of IgG antibodies by the mother against the paternally inherited antigens (IPA) in the foetus/newborn.

The alloimmunization during pregnancy leads to various alloimmune disorders, such as, haemolytic disease of the foetus and newborn (HDFN), neonatal alloimmune neutropenia (NAN) and foetal and neonatal Author: Meenakshi Singh, Jyoti Rajak, Shalaka Kadam, Sunil B.

Rajadhyaksha. Differential Diagnosis. Neonatal thrombocytopenia is a relatively rare condition with a prevalence of % in unselected populations. 2 FMAIT is the most common cause of severe thrombocytopenia in the newborn, accounting for 3% of all fetal and neonatal thrombocytopenia and 27% of severe cases (defined as Cited by: Alloimmune Disorders of Pregnancy.

Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn Article in Transfusion Medicine 12(5) October with 24 Reads. Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the commonest cause of severe neonatal thrombocytopenia.

FNAIT is usually suspected in neonates with bleeding or severe, unexplained, and/or isolated postnatal thrombocytopenia. Affected fetuses should be managed in referral centers with experience in the ante-natal management of by: 2. Thrombocytopenia develops in 5% to 10% of women during pregnancy or in the immediate postpartum period.

A low platelet count is often an incidental feature, but it might also provide a biomarker of a coexisting systemic or gestational disorder and a potential reason for a maternal intervention or treatment that might pose harm to the by: alloimmune: (al'ō-im-yūn'), Immune to an allogenic antigen.

[allo- + immune]. This book will offer a comprehensive guide to disorders of thrombosis and haemostasis in pregnancy. It will highlight the latest developments and controversial issues. The multidisciplinary approach will provide authoritative clinical advice on state-of-the-art management.

The disorders to be covered are highly pertinent to successful pregnancy outcome, and many may be associated with. Neonatal alloimmune thrombocytopenia (NAIT), also referred to as fetal and neonatal alloimmune thrombocytopenia or perinatal alloimmune thrombocytopenia, is the most common cause of thrombocytopenia in an otherwise healthy newborn.

NAIT is caused by alloantibodies formed by the mother in response to a paternally inherited human platelet antigen (HPA) that is on the surface of. / Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin.

In: American Journal of Reproductive Immunology. ; Cited by: 1 Pathophysiology of the alloimmune cytopenias Andrew G Hadley1 and Craig Turner2 1 International Blood Group Reference Laboratory, Bristol, UK 2 Bristol Institute for Transfusion Sciences, Bristol, UK The pathogenesis of the alloimmune cytopenias can be considered in four stages: alloimmunization of the mother, the placental transfer of antibodies to a fetus, the.

Maternal-fetal medicine has evolved over the last three decades to become a well-established discipline. The current understanding of maternal physiology and pathophysiology has allowed us to obtain more accurate diagnoses and to provide more effective treatments of medical, surgical, and obstetrical maternal complications.

More importantly, the fetus has become a distinct 5/5(1). Neonatal alloimmune thrombocytopenia Maria Teresa Mella, Keith A Eddleman Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Mount Sinai School of Medicine, New York, NY, USA Abstract: Neonatal alloimmune thrombocytopenia occurs in one in 1,–1, live births and is the most common cause of severe thrombocytopenia and intracranial hemorrhage in term infants.

regard, this book has much to commend it. It will provide the prospective reader with a comprehensive, well-referenced and up to date overview of alloimmune disorders of pregnancy.

This is a confusing area of fetal medicine and the explanations and practical approach that the book presents wdl make it Author: Patrick Hogston.

Neonatal alloimmune thrombocytopenia affects % of births, with maternal antibodies crossing the placenta as early as 14 weeks’ gestation.

It is the most common cause of severely low platelets (thrombocytopenia) in an otherwise well neonate and may cause bleeding into major organs such as the stomach or spinal cord. The alloimmune hypothesis has been confirmed by studies showing the involvement of complement in the pathogenesis of hepatocyte injury, which could result only from maternal alloimmunity [8].

Neonatal Liver Failure and Congenital Cirrhosis due to Gestational Alloimmune Liver Disease: A Case Report and Literature Review. cation of the book titled Alloimmune disorders of pregnancy: anaemia, thrombocytopenia, and neutropenia in the foetus and neonate edited by Dr Hadley and Professor Soothill will provide a useful and handy reference.

Since the effect-ive prevention, diagnosis, and management of these dis-orders require nothing less than the combined efforts of.

Alloimmune hemolytic disease of the fetus and newborn (HDFN) is a disorder in which the life span of fetal and/or neonatal red cells is shortened as a result of binding of transplacentally transferred maternal immunoglobulin (Ig) G antibodies on fetal red blood cell (RBC) antigens foreign to the mother, inherited by the fetus from the father.

Louis, MO: Mosby-year book Inc; Vol 1: Smits-Wintjens VE, Rath ME, van Zwet EW, et al. Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease. 1 Pathophysiology of the alloimmune cytopenias Andrew G Hadley 1 and Craig Turner2 1 International Blood Group Reference Laboratory, Bristol, UK 2 Bristol Institute for Transfusion Sciences, Bristol, UK The pathogenesis ofthe alloimmune cytopenias can be considered in four stages: alloimmunization ofthe mother, the placental transfer ofantibodies to a fetus, the.

Other articles where Autoimmune disease is discussed: immune system disorder: Autoimmune disorders: The mechanism by which the enormous diversity of B and T cells is generated is a random process that inevitably gives rise to some receptors that recognize the body’s own constituents as foreign.

Lymphocytes bearing such self-reactive receptors, however, are eliminated or rendered. This book is an updated comprehensive guide to disorders of thrombosis and haemostasis in pregnancy ; The book provides authoritative, practical clinical advice on the management of women with both common and rare disorders of thrombosis and haemostasis, in the context of available scientific evidence.

The Journal of Autoimmunity publishes papers related to the diverse aspects of autoimmunity: the mechanism of self-recognition, regulation of autoimmune responses, experimental autoimmune diseases, diagnostic autoantibody tests, and the epidemiology, pathophysiology, and treatment of autoimmune diseases.

Special, but not exclusive, attention.Background: Gestational alloimmune liver disease, a form of profound liver failure in the newborn, is the main underlying cause of the entity formerly known as neonatal hemochromatosis.This chapter describes the epidemiology, clinical diagnosis, and clinical significance of Fetal and neonatal alloimmune thrombocytopenia (FNAIT) in pregnancy.

FNAIT is the commonest cause of severe neonatal thrombocytopenia, and is analogous to the fetal/neonatal anemia caused by hemolytic disease of the fetus and newborn (HDFN).

18385 views Wednesday, November 11, 2020